Pirates vs. Reds Predictions & Picks: Odds, Moneyline, Spread - September 22

Friday's contest between the Cincinnati Reds (79-75) and Pittsburgh Pirates (72-81) squaring off at Great American Ball Park has a projected final score of 5-3 (according to our computer prediction) in favor of the Reds, so expect a tight matchup. The game will begin at 6:40 PM ET on September 22.

The Reds will give the ball to Andrew Abbott (8-5, 3.68 ERA), who is eyeing win No. 9 on the season, and the Pirates will turn to Andre Jackson (1-3, 5.40 ERA).

Pirates vs. Reds Game Info & Odds

• When: Friday, September 22, 2023 at 6:40 PM ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to Watch on TV: BSOH
• Live Stream: Watch this game on Fubo!

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Pirates vs. Reds Score Prediction

Our prediction for this matchup is Reds 5, Pirates 4.

Total Prediction for Pirates vs. Reds

• Total Prediction: Under 9.5 runs

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Read More About This Game

• Pirates Injury Report

• Reds vs Pirates Betting Trends & Stats

• Reds vs Pirates Pitching Matchup

• How to Watch Reds vs Pirates

• Reds vs Pirates Odds

Pirates Performance Insights

• In six games as the underdog over the last 10 matchups, the Pirates have a record of 3-3.
• In its last 10 matchups with a total posted by sportsbooks, Pittsburgh and its opponents are 5-5-0 when it comes to hitting the over.
• The Pirates' previous 10 matchups have not had a runline set by sportsbooks.
• The Pirates have won in 52, or 43%, of the 121 contests they have been named as odds-on underdogs this year.
• This season, Pittsburgh has come away with a win 23 times in 48 chances when named as an underdog of at least +135 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Pirates have a 42.6% chance of pulling out a win.
• Pittsburgh scores the 23rd-most runs in baseball (650 total, 4.2 per game).
• The Pirates have pitched to a 4.58 ERA this season, which ranks 21st in baseball.

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